Sleep and circadian patterns predict the onset, severity, and persistence of mental disorders. During adolescence and young adulthood, developmentally normative changes in sleep and circadian patterns (e.g., short sleep duration, late sleep timing) may exacerbate risk. My work evaluates a developmental model in which sleep and circadian patterns contribute to psychopathology in adolescents and young adults through multiple systems – reward-related brain function, autonomic stress response, and multi-system bioregulatory response to stressors. This keynote presentation will begin with a description of foundational research that links sleep and circadian patterns in adolescents and young adults to reward-related brain function, autonomic stress response, and biomarkers of cumulative stressor exposure. I will then describe ongoing work that evaluates the degree to which short-and-late sleep contributes to symptoms of depression in adolescents through disruptions in reward-related brain function, autonomic stress response, and bioregulatory response to cumulative stressors. The long-term objective of this research is to improve resilience to the ‘storm and stress’ of adolescence and young adulthood by optimizing sleep-circadian health behaviors during critical periods of development.